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We generated a worldwide autosomal STR DNA database (http://www.strdna-db.org) for use by the forensic genetics community. The interface is user-friendly, allowing an easy visualisation of geographic location of samples and an easy export of allelic frequencies for further genetic comparisons.
Worldwide genetic databases are useful tools in forensic genetics, given that any individual profile must be compared against a population dataset. Some recent catastrophes called the attention to the inexistence of an easy-available worldwide autosomal database, for evaluation of the multiethnic genetic profiles.
The database implemented in this work collects published data in the main forensic international journals for autosomal short tandem repeats (STRs), at a worldwide scale. Publications reporting at least six of the most used markers were included. The STRs considered were CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, Penta D, Penta E, TH01, TPO and vWA.
The database will have the obvious limitation of not performing a quality control of data, relying on the acceptance criteria used by the main forensic international journals.
A user-friendly web interface was developed, with geographical disclosure on a Googlemap, so that users can easily identify which populations are already surveyed in different worldwide regions (Fig. 1). The interface was optimised to be used on Internet Explorer browser.
Fig. 1Layout of the database when selecting the region sub-Saharan Africa, displaying samples already deposited in the database.
The allelic frequencies for each sample are displayed in an excel file, easily exportable for further comparisons.
3. Future developments
The broad geographical scale aimed in this database will for sure contribute new insights on general STRs informative power and on population genetics analyses.
In the near future we intend to implement a calculation of match probabilities of DNA profiles [
IPATIMUP is supported by Programa Operacional Ciência, Tecnologia e Inovação (POCTI), Quadro Comunitário de Apoio III. The sponsor had no involvement in the development of the paper or decision related to the paper.
Conflict of interest
None.
Acknowledgment
IPATIMUP is supported by Programa Operacional Ciência, Tecnologia e Inovação (POCTI), Quadro Comunitário de Apoio III.
Reference
Gill P.
Foreman L.
Buckleton J.S.
Triggs C.M.
Allen H.
A comparison of adjustment methods to test the robustness of an STR DNA database comprised of 24 European populations.
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