Forensic Science International: Genetics Supplement Series
Volume 2, Issue 1 , Pages 14-16 , December 2009

Forensic STR analysis reveals DNA contamination previously undetected during clinical analysis of chronically inflamed tissues

  • G.L. Axler-DiPerte

      Affiliations

    • New York City Office of Chief Medical Examiner, Department of Forensic Biology, 421 E. 26th Street, New York, NY 10016, USA
    • ,
  • E. Wurmbach

      Affiliations

    • New York City Office of Chief Medical Examiner, Department of Forensic Biology, 421 E. 26th Street, New York, NY 10016, USA
    • ,
  • Z.M. Budimlija

      Affiliations

    • New York City Office of Chief Medical Examiner, Department of Forensic Biology, 421 E. 26th Street, New York, NY 10016, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 323 1267; fax: +1 212 323 1590.
    • ,
  • B. Jian

      Affiliations

    • University of Pennsylvania School of Medicine, Department of Pathology, Philadelphia, PA, USA
    • ,
  • F. Fogt

      Affiliations

    • University of Pennsylvania School of Medicine, Department of Pathology, Philadelphia, PA, USA
    • ,
  • M. Prinz

      Affiliations

    • New York City Office of Chief Medical Examiner, Department of Forensic Biology, 421 E. 26th Street, New York, NY 10016, USA

Received 13 August 2009 ,Accepted 14 August 2009.

References 

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  2. Itzkowitz S. Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice. J. Clin. Gastroenterol. 2003;36(5 Suppl.):S70–S74(discussion S94-6)
  3. Wright CM, et al. Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma. Gut. 2005;54(1):103–108
  4. Budimlija Z, et al. Malignant tumors and forensics—dilemmas and proposals. Croat. Med. J. 2009;50(3):218–227
  5. Vauhkonen H, et al. Evaluation of gastrointestinal cancer tissues as a source of genetic information for forensic investigations by using STRs. Forensic Sci. Int. 2004;139(2-3):159–167
  6. Ekbom A, et al. Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med. 1990;323(18):1228–1233
  7. Popiolek DA, et al. Multiplex DNA short tandem repeat analysis. A useful method for determining the provenance of minute fragments of formalin-fixed, paraffin-embedded tissue. Am. J. Clin. Pathol. 2003;120(5):746–751
  8. Cawkwell L, Lewis FA, Quirke P. Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br. J. Cancer. 1994;70(5):813–818
  9. Lovig T, et al. Microsatellite instability in long-standing ulcerative colitis. Scand. J. Gastroenterol. 2007;42(5):586–591
  10. Yoon BS, et al. Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors. Yonsei Med. J. 2008;49(2):272–278

PII: S1875-1768(09)00094-8

doi: 10.1016/j.fsigss.2009.08.059

Forensic Science International: Genetics Supplement Series
Volume 2, Issue 1 , Pages 14-16 , December 2009

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