Mitochondrial DNA sequence analysis of native Bolivians population

Afonso Costa, H.; Lopes, V.; Balsa, F.; Bento, A.M.; Pantoja, S.; Anjos, M.J.; Carvalho, M.; Vide, M.C.; Vieira, D.N.; Corte-Real, F.

doi:10.1016/j.fsigss.2007.10.090

« Previous Next »Forensic Science International: Genetics Supplement Series
Volume 1, Issue 1 , Pages 259-261, August 2008

Mitochondrial DNA sequence analysis of native Bolivians population

H. Afonso Costa
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
- Corresponding author at: Serviço de Genética Forense, Delegação do Centro, Instituto Nacional de Medicina Legal, Largo da Sé Nova, 3000-213 Coimbra, Portugal. Tel.: +351 239 854 230; fax: +351 239 820 549.
V. Lopes
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
F. Balsa
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
A.M. Bento
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
S. Pantoja
- University of La Paz, Bolívia
M.J. Anjos
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
M. Carvalho
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
M.C. Vide
- Forensic Genetic Service, Central Region Department, National Institute of Legal Medicine, Portugal
D.N. Vieira
- National Institute of Legal Medicine, Portugal
F. Corte-Real
- National Institute of Legal Medicine, Portugal

Received 20 August 2007; accepted 10 October 2007.

Abstract

Haplotypes of 111 individuals from La Paz have been studied by the analysis of the polymorphisms in mtDNA control region, HV1 and HV2 regions, in order to intend the genetic diversity. The aim was to created a population database, assess genetic interpopulation variability and classify haplogroups. We had identify 99 haplotypes with 125 polymorphic nucleotide positions, 93 haplotypes are unique. Nucleotide and sequence diversity are estimated in 0.016068±0.008186 and 0.9988, respectively. Haplogroup distribution is as follows: 47.75% B; 14.41% C; 6.31% A; 4.5% D; 6.31% A, C, or D; 23.42% undetermined or compound haplogroups. Rate of heteroplasmy is 37.8% in HV1 and 53.2% in HV2.